Across TCGA pan-cancer cohorts, NPIPB15 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NPIPB15’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where NPIPB15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPIPB15 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

LIHC, KIRC, and READ are the cancer types where NPIPB15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPIPB15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	All	+0.418	.041	2	view →
KIRC	All	All	+0.324	.012	2	view →
READ	Female	All	+1.536	.012	1	view →
STAD	Male	IV	−0.024	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: NPIPB15 RNA expression & survival · all NPIPB15 data types