NPIPB11

Across TCGA cell cohorts, NPIPB11 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NPIPB11-associated genes across cancer lineages are NEUROD4, GJE1, and USP17L13. Each is linked with NPIPB11 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPIPB11-to-partner and partner-to-NPIPB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROD4 grouped by NPIPB11-low versus NPIPB11-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPIPB11→partner) and Y-score (partner→NPIPB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NEUROD4 →	+0.037	+3.106	<.001	.005	3	2
LUNG_SCLC	GJE1 →	+0.026	+5.643	<.001	.002	3	1
LUNG_SCLC	USP17L13 →	+0.013	+5.029	<.001	.006	3	1
LUNG_SCLC	USP17L17 →	+0.013	+5.029	<.001	.006	3	1
BREAST	CHRNB3 →	+0.010	+4.781	<.001	.003	3	1
BREAST	ZNF735 →	+0.025	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

NEUROD4 by NPIPB11 expression — BLOOD_Leukemia

Explore this box plot interactively →