Across TCGA pan-cancer cohorts, NPIPA7 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of NPIPA7’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where NPIPA7 RNA is repressed in tumor relative to normal tissue. In most cancer types NPIPA7 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC are the cancer types where NPIPA7 tumor–normal differential expression is most reproducible.