Across TCGA patient cohorts, NPIPA1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPIPA1-associated genes across cancer lineages are Ku80, MEK1, and PCNA. Each is linked with NPIPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPIPA1-to-partner and partner-to-NPIPA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPIPA1→partner) and Y-score (partner→NPIPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.273	+2.183	.027	.035	3	1
UCEC	MEK1 →	+0.472	+3.169	.013	.019	3	1
UCEC	PCNA →	+0.302	+3.000	.007	.036	3	1
UCEC	VHL →	-0.937	-3.000	.008	.036	3	1
UCEC	ATM →	-0.719	-2.986	.002	.035	3	1
UCEC	Caspase-8 →	-0.316	-2.973	.016	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

NPIPA1 survival (RNA) · tumor vs normal (RNA) · all NPIPA1 data types