NPHS2

Across TCGA patient cohorts, NPHS2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPHS2-associated genes across cancer lineages are PCNA, AMPK_alpha, and Cyclin-B1. Each is linked with NPHS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPHS2-to-partner and partner-to-NPHS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NPHS2-low versus NPHS2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHS2→partner) and Y-score (partner→NPHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.345	+3.000	.001	.036	3	2
UCEC	AMPK_alpha →	-0.178	-3.169	.023	.018	3	2
UCEC	Cyclin-B1 →	+0.644	+2.321	.005	.006	3	2
SKCM	FOXO3a →	-0.150	-3.000	.023	.035	3	1
UCEC	EGFR_pY1068 →	-0.211	-1.807	.042	.027	3	1
UCEC	EGFR →	-0.221	-3.143	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PCNA by NPHS2 expression — SKCM

Explore this box plot interactively →