NPHS2

Across TCGA cell cohorts, NPHS2 RNA expression is significantly associated with the mutation status of many other genes, with 160 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPHS2-associated genes across cancer lineages are UNC13C, CNTN4, and HUWE1. Each is linked with NPHS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPHS2-to-partner and partner-to-NPHS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC13C grouped by NPHS2-low versus NPHS2-high in OESOPHAGUS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHS2→partner) and Y-score (partner→NPHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	UNC13C →	+3.273	+0.005	.004	<.001	3	2
SOFT_TISSUE	CNTN4 →	+3.297	+0.010	.008	<.001	3	2
BLOOD_Lymphoma	HUWE1 →	+2.777	+0.013	.002	.003	3	2
URINARY_TRACT	ZNF516 →	+4.044	+0.150	.001	.001	3	2
URINARY_TRACT	CCDC40 →	+5.044	+0.187	<.001	<.001	3	2
URINARY_TRACT	PLA2G4D →	+5.044	+0.187	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 160 associations by consensus.

UNC13C by NPHS2 expression — OESOPHAGUS

Explore this box plot interactively →