NPHS2

Across TCGA cell cohorts, NPHS2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPHS2-associated genes across cancer lineages are WFDC8, SSX5, and RESP18. Each is linked with NPHS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPHS2-to-partner and partner-to-NPHS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC8 grouped by NPHS2-low versus NPHS2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHS2→partner) and Y-score (partner→NPHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WFDC8 →	+0.014	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	SSX5 →	+1.311	+3.343	<.001	.005	3	1
LUNG_NSCLC_LUAD	RESP18 →	+0.019	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	CD200R1L →	+0.046	+3.832	.005	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1
LARGE_INTESTINE	FAM153B →	+0.679	+3.748	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

WFDC8 by NPHS2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →