NPHP3

Across TCGA patient cohorts, NPHP3 protein abundance is significantly associated with the RNA expression of many other genes, with 5,018 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NPHP3-associated genes across cancer lineages are PPP2CB, EPHX2, and PTP4A2. Each is linked with NPHP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPHP3-to-partner and partner-to-NPHP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPHP3 versus PPP2CB in OV, with a Pearson correlation of -0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP3→partner) and Y-score (partner→NPHP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PPP2CB →	-0.917	-0.570	<.001	.007	3	2
CCRCC	EPHX2 →	-2.032	-0.902	<.001	<.001	3	2
CCRCC	PTP4A2 →	+0.712	+0.810	<.001	<.001	3	2
LSCC	SPACA6 →	+0.675	+0.297	.009	.007	3	2
BRCA	LINC01943 →	+0.760	+0.794	<.001	.004	3	2
CCRCC	RNU2-7P →	-1.188	-0.838	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,018 associations by consensus.

NPHP3 vs PPP2CB — OV

Explore this scatter interactively →