NPHP3

Across TCGA patient cohorts, NPHP3 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPHP3-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and GSK-3a-b_pS21_S9. Each is linked with NPHP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPHP3-to-partner and partner-to-NPHP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NPHP3-low versus NPHP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP3→partner) and Y-score (partner→NPHP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.398	+2.107	.033	.002	3	3
UCEC	MEK1 →	+0.319	+1.353	.005	.015	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.369	+1.594	.006	.005	3	2
UCEC	PDCD4 →	-0.304	-1.874	.040	.049	3	2
UCEC	Tuberin_pT1462 →	+0.261	+1.847	<.001	.007	3	2
UCEC	ASNS →	+0.391	+2.321	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by NPHP3 expression — UCEC

Explore this box plot interactively →