NPHP3

Across TCGA cell cohorts, NPHP3 mutation is significantly associated with the RNA expression of many other genes, with 168 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPHP3-associated genes across cancer lineages are GDF10, HTR3D, and HCRT. Each is linked with NPHP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPHP3-to-partner and partner-to-NPHP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDF10 grouped by NPHP3-low versus NPHP3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP3→partner) and Y-score (partner→NPHP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GDF10 →	+0.186	+4.115	<.001	.001	3	2
BLOOD_Lymphoma	HTR3D →	+0.012	+4.662	<.001	.003	3	2
SOFT_TISSUE	HCRT →	+0.054	+4.417	.001	.004	3	1
SOFT_TISSUE	RTL4 →	+0.016	+4.369	.001	.008	3	1
OESOPHAGUS	AQP9 →	+0.034	+3.652	<.001	.006	3	1
OESOPHAGUS	ELSPBP1 →	+0.304	+3.392	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 168 associations by consensus.

GDF10 by NPHP3 expression — OESOPHAGUS

Explore this box plot interactively →