NPHP3-AS1

Across TCGA pan-cancer cohorts, NPHP3-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NPHP3-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher NPHP3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPHP3-AS1 expression acts as an unfavorable survival marker, although some lineages such as THCA and SKCM show a favorable association.

LUSC, LGG, and COAD are the cancer types where NPHP3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	III,IV	0.196	0.512	<.001	51	view →
LGG	OS	Median	All	0.374	0.511	<.001	43	view →
COAD	OS	Tertile	II,III,IV	0.421	0.687	.008	40	view →
ACC	DFS	Tertile	All	0.094	0.712	<.001	38	view →
BLCA	DFS	Tertile	IV	0.110	0.341	.005	36	view →
LIHC	OS	Median	All	0.511	0.771	<.001	34	view →
MESO	OS	Tertile	III,IV	0.404	0.623	.005	27	view →
UCEC	DFS	Quartile	All	0.791	0.905	.003	22	view →
CHOL	DFS	Tertile	III,IV	0.162	0.779	.024	12	view →
ESCA	OS	Quartile	IV	0.135	0.674	.038	12	view →
THCA	DFS	Median	IV	1.000	0.563	.006	11	view →
SKCM	DFS	Quartile	All	0.282	0.158	.030	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NPHP3-AS1–LUSC (DFS)

Open the LUSC breakdown →