NPFFR2

Across TCGA patient cohorts, NPFFR2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPFFR2-associated genes across cancer lineages are PDCD4, PCNA, and JNK_pT183_Y185. Each is linked with NPFFR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPFFR2-to-partner and partner-to-NPFFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by NPFFR2-low versus NPFFR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPFFR2→partner) and Y-score (partner→NPFFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.499	-2.906	<.001	.001	3	3
SKCM	PCNA →	+0.238	+3.000	.013	.034	3	2
UCEC	JNK_pT183_Y185 →	-0.128	-1.340	.015	.015	3	2
UCEC	Notch1 →	+0.144	+1.515	.001	.015	3	2
UCEC	p62 Lck ligand →	+0.384	+2.432	<.001	<.001	3	2
UCEC	TFRC →	+0.396	+1.700	.017	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PDCD4 by NPFFR2 expression — UCEC

Explore this box plot interactively →