NPFFR1

Across TCGA patient cohorts, NPFFR1 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPFFR1-associated genes across cancer lineages are IGHD1-26, MIR1266, and MYF5. Each is linked with NPFFR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPFFR1-to-partner and partner-to-NPFFR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD1-26 grouped by NPFFR1-low versus NPFFR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPFFR1→partner) and Y-score (partner→NPFFR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD1-26 →	+0.916	+3.484	<.001	.004	3	2
UCEC	MIR1266 →	+0.248	+3.771	.004	.002	3	2
CESC	MYF5 →	+0.087	+5.812	<.001	.003	3	2
CESC	RNU1-17P →	+0.459	+5.103	<.001	.008	3	2
COAD	RNU6-1246P →	+1.377	+7.741	<.001	.009	3	2
SKCM	RPS24P1 →	+0.567	+5.555	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

IGHD1-26 by NPFFR1 expression — UCEC

Explore this box plot interactively →