NPFFR1

Across TCGA cell cohorts, NPFFR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,862 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NPFFR1-associated GO terms across cancer lineages are Positive regulation of Rho protein signal transduction, Protein localization to plasma membrane, and Positive regulation of viral life cycle. Each is linked with NPFFR1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NPFFR1-to-partner and partner-to-NPFFR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of Rho protein signal transduction grouped by NPFFR1-low versus NPFFR1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPFFR1→partner) and Y-score (partner→NPFFR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of Rho protein signal transduction →	+0.103	+0.246	<.001	.007	3	6
LUNG_NSCLC_LUSC	Protein localization to plasma membrane →	+0.067	+0.022	.002	.004	2	6
UPPER_AERODIGESTIVE_TRACT	Positive regulation of viral life cycle →	+0.092	+0.039	.001	.002	3	5
SKIN	Negative regulation of RNA splicing →	+0.060	+0.025	.003	.007	3	5
LARGE_INTESTINE	Spliceosomal tri-snRNP complex assembly →	+0.059	+0.340	.008	.007	2	6
LARGE_INTESTINE	Protein localization to cell surface →	+0.089	+0.384	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,862 associations by consensus.

Positive regulation of Rho protein signal transduction by NPFFR1 expression — PANCREAS

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