NPFF

Across TCGA pan-cancer cohorts, NPFF Mutation is linked to patient survival in 3 of 34 cancer types, making it the most broadly survival-associated NPFF data layer compared with 1 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher NPFF Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NPFF expression acts as an unfavorable survival marker.

READ, PRAD, and BRCA are the cancer types where NPFF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.054	0.934	<.001	24	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BRCA	DFS	Median	All	0.294	0.903	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NPFF–READ (OS)

Open the READ breakdown →