NPFF

Across TCGA patient cohorts, NPFF RNA expression is significantly associated with the go_rna of many other GO terms, with 654 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible NPFF-associated GO terms across cancer lineages are Golgi to lysosome transport, Cellular senescence, and Telomeric loop disassembly. Each is linked with NPFF in more than 1 cancer types. Because this analysis shows association rather than direction, both NPFF-to-partner and partner-to-NPFF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi to lysosome transport grouped by NPFF-low versus NPFF-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPFF→partner) and Y-score (partner→NPFF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Golgi to lysosome transport →	+0.093	+0.835	<.001	<.001	3	1
SCLC	Cellular senescence →	+0.110	+1.300	<.001	<.001	3	1
SCLC	Telomeric loop disassembly →	+0.087	+0.959	<.001	<.001	3	1
SCLC	Aromatic amino acid metabolic process →	-0.116	-1.416	<.001	<.001	3	1
SCLC	Nucleoside metabolic process →	-0.092	-0.806	<.001	<.001	3	1
SCLC	Deoxyribonucleoside monophosphate catabolic process →	-0.208	-1.388	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 654 associations by consensus.

Golgi to lysosome transport by NPFF expression — SCLC

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