NPFF

Across TCGA patient cohorts, NPFF mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPFF-associated genes across cancer lineages are OR5P1P, IGHD6-19, and RNU6-855P. Each is linked with NPFF in more than 1 cancer types. Because this analysis shows association rather than direction, both NPFF-to-partner and partner-to-NPFF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5P1P grouped by NPFF-low versus NPFF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPFF→partner) and Y-score (partner→NPFF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR5P1P →	+0.109	+5.186	<.001	.007	3	1
UCEC	IGHD6-19 →	+1.701	+5.420	<.001	.005	3	1
UCEC	RNU6-855P →	+0.711	+7.470	<.001	<.001	3	1
UCEC	RN7SKP166 →	+0.362	+5.299	.002	.006	3	1
UCEC	CDK4P1 →	+0.118	+5.186	.003	.007	3	1
UCEC	MAGEB6B →	+0.229	+5.081	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR5P1P by NPFF expression — UCEC

Explore this box plot interactively →