NPFF

Across TCGA cell cohorts, NPFF RNA expression is significantly associated with the go_rna of many other GO terms, with 1,940 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NPFF-associated GO terms across cancer lineages are Vasopressin secretion, Positive regulation of protein K48-linked ubiquitination, and Meiotic chromosome separation. Each is linked with NPFF in more than 8 cancer types. Because this analysis shows association rather than direction, both NPFF-to-partner and partner-to-NPFF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vasopressin secretion grouped by NPFF-low versus NPFF-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPFF→partner) and Y-score (partner→NPFF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Vasopressin secretion →	-0.726	-0.300	<.001	<.001	3	9
BONE	Positive regulation of protein K48-linked ubiquitination →	-0.097	-0.547	<.001	<.001	3	6
BLOOD_Lymphoma	Meiotic chromosome separation →	+0.107	+0.156	.001	.002	3	5
LIVER	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.205	+0.248	.002	.002	3	5
BLOOD_Lymphoma	Free ubiquitin chain polymerization →	+0.101	+0.216	<.001	.001	3	4
BLOOD_Lymphoma	Protein ufmylation →	-0.075	-0.203	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,940 associations by consensus.

Vasopressin secretion by NPFF expression — CNS

Explore this box plot interactively →