NPEPPS

Across TCGA pan-cancer cohorts, NPEPPS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NPEPPS data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NPEPPS mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NPEPPS expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where NPEPPS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.977	0.810	.004	42	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	7	view →
CCRCC	OS	Quartile	All	0.714	0.888	.020	5	view →
LUAD	OS	Tertile	II,III,IV	0.320	0.879	.012	5	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.858	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NPEPPS–HNSC (OS)

Open the HNSC breakdown →