NPEPPS

Across TCGA patient cohorts, NPEPPS mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPEPPS-associated genes across cancer lineages are JNK2, MEK1, and PCNA. Each is linked with NPEPPS in more than 1 cancer types. Because this analysis shows association rather than direction, both NPEPPS-to-partner and partner-to-NPEPPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by NPEPPS-low versus NPEPPS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPEPPS→partner) and Y-score (partner→NPEPPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.200	+2.232	.004	.005	3	1
UCEC	MEK1 →	+0.281	+1.662	.029	.011	3	1
UCEC	PCNA →	+0.158	+3.459	.039	.005	3	1
UCEC	PDK1_pS241 →	+0.145	+2.222	.016	.010	3	1
UCEC	Rad50 →	-0.196	-3.156	.022	.018	3	1
UCEC	STAT3_pY705 →	-0.327	-2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by NPEPPS expression — UCEC

Explore this box plot interactively →