NPEPPS

Across TCGA cell cohorts, NPEPPS mutation is significantly associated with the drug of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPEPPS-associated genes across cancer lineages are Oxaliplatin, Ispinesib Mesylate, and AZD1208. Each is linked with NPEPPS in more than 1 cancer types. Because this analysis shows association rather than direction, both NPEPPS-to-partner and partner-to-NPEPPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxaliplatin grouped by NPEPPS-low versus NPEPPS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPEPPS→partner) and Y-score (partner→NPEPPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Oxaliplatin →	+0.608	+2.649	.021	.046	2	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.701	+2.652	.031	.045	2	1
LARGE_INTESTINE	AZD1208 →	+0.391	+2.649	.023	.046	1	1
LARGE_INTESTINE	ZSTK474 →	+0.585	+2.786	.025	.037	1	1
LARGE_INTESTINE	NSC-207895 →	+0.500	+2.786	.020	.037	1	1
LARGE_INTESTINE	Pelitinib →	+0.728	+2.786	.024	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Oxaliplatin by NPEPPS expression — LARGE_INTESTINE

Explore this box plot interactively →