NPDC1

Across TCGA pan-cancer cohorts, NPDC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NPDC1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NPDC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NPDC1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, HNSC, and UCEC are the cancer types where NPDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.593	0.276	.003	29	view →
HNSC	OS	Tertile	III,IV	0.509	0.757	.017	15	view →
UCEC	DFS	Median	All	0.952	0.853	.020	6	view →
GBM	OS	Median	All	0.284	0.464	.007	6	view →
LUAD	DFS	Median	All	0.756	0.422	.011	6	view →
LSCC	DFS	Median	III,IV	0.590	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NPDC1–PDAC (DFS)

Open the PDAC breakdown →