NPC1

Across TCGA pan-cancer cohorts, NPC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NPC1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NPC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where NPC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.908	1.000	.009	96	view →
CCRCC	DFS	Quartile	III,IV	0.347	0.837	<.001	38	view →
PDAC	DFS	Median	All	0.320	0.493	.005	30	view →
HNSC	DFS	Quartile	II,III,IV	0.920	0.740	.023	8	view →
LSCC	OS	Tertile	All	0.905	0.743	.021	5	view →
GBM	DFS	Quartile	All	0.681	0.817	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NPC1–COAD (DFS)

Open the COAD breakdown →