NPC1

Across TCGA patient cohorts, NPC1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,593 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPC1-associated genes across cancer lineages are RMC1, GIMAP6, and SPP1. Each is linked with NPC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NPC1-to-partner and partner-to-NPC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPC1 versus RMC1 in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC1→partner) and Y-score (partner→NPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RMC1 →	+0.634	+0.440	<.001	<.001	3	5
UCEC	GIMAP6 →	-0.842	-0.367	<.001	.003	3	5
COAD	SPP1 →	+1.899	+0.269	<.001	.002	3	4
CCRCC	MMRN2 →	-0.736	-0.338	<.001	<.001	3	4
UCEC	ZSCAN26 →	-0.762	-0.387	<.001	<.001	3	4
UCEC	FTLP2 →	+1.741	+0.339	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,593 associations by consensus.

NPC1 vs RMC1 — OV

Explore this scatter interactively →