NPC1

Across TCGA patient cohorts, NPC1 mutation is significantly associated with the RNA expression of many other genes, with 6,120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPC1-associated genes across cancer lineages are VPS18, ABHD5, and GOT1. Each is linked with NPC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NPC1-to-partner and partner-to-NPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VPS18 grouped by NPC1-low versus NPC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC1→partner) and Y-score (partner→NPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VPS18 →	+0.486	+2.700	.001	.006	3	4
UCEC	ABHD5 →	+0.655	+2.168	<.001	<.001	3	4
STAD	GOT1 →	+0.648	+3.338	.001	.005	3	4
COAD	TXNL4A →	+0.502	+3.710	<.001	<.001	3	4
COAD	PUSL1 →	+0.507	+3.459	.003	.005	3	4
COAD	ELAC2 →	+0.541	+3.847	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,120 associations by consensus.

VPS18 by NPC1 expression — COAD

Explore this box plot interactively →