NPC1

Across TCGA patient cohorts, NPC1 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPC1-associated genes across cancer lineages are ATM, 4E-BP1_pT37_T46, and 14-3-3_beta. Each is linked with NPC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPC1-to-partner and partner-to-NPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NPC1-low versus NPC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC1→partner) and Y-score (partner→NPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.482	-2.807	.001	.003	3	3
UCEC	4E-BP1_pT37_T46 →	-0.262	-1.687	.040	.040	3	3
UCEC	14-3-3_beta →	-0.077	-1.973	.024	.029	3	2
UCEC	ERK2 →	+0.178	+1.906	.006	.014	3	2
UCEC	IGFBP2 →	-0.652	-1.514	.003	.015	3	2
UCEC	JNK2 →	+0.273	+2.523	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ATM by NPC1 expression — UCEC

Explore this box plot interactively →