NPC1

Across TCGA cell cohorts, NPC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,673 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NPC1-associated GO terms across cancer lineages are Lysosome to ER cholesterol transport, Intestinal cholesterol absorption, and Membrane raft organization. Each is linked with NPC1 in more than 16 cancer types. Because this analysis shows association rather than direction, both NPC1-to-partner and partner-to-NPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosome to ER cholesterol transport grouped by NPC1-low versus NPC1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC1→partner) and Y-score (partner→NPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Lysosome to ER cholesterol transport →	+0.193	+1.481	<.001	<.001	3	17
STOMACH	Intestinal cholesterol absorption →	+0.344	+1.529	.002	.001	3	14
BONE	Membrane raft organization →	+0.213	+1.711	<.001	<.001	3	13
BREAST	Lipid digestion →	+0.386	+1.613	<.001	<.001	3	13
STOMACH	Biological process involved in symbiotic interaction →	+0.098	+1.223	<.001	<.001	3	12
BONE	Symbiont entry into host →	+0.153	+1.641	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,673 associations by consensus.

Lysosome to ER cholesterol transport by NPC1 expression — PANCREAS

Explore this box plot interactively →