NPC1

Across TCGA cell cohorts, NPC1 mutation is significantly associated with the RNA expression of many other genes, with 1,544 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPC1-associated genes across cancer lineages are PNLIPRP1, OR12D2, and IFNA5. Each is linked with NPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPC1-to-partner and partner-to-NPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNLIPRP1 grouped by NPC1-low versus NPC1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC1→partner) and Y-score (partner→NPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PNLIPRP1 →	+0.293	+4.321	<.001	.009	3	2
BLOOD_Lymphoma	OR12D2 →	+0.042	+4.643	<.001	.005	3	2
LUNG_NSCLC_LUAD	IFNA5 →	+0.033	+3.415	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR7G2 →	+0.013	+3.472	<.001	.004	3	1
LUNG_NSCLC_LUAD	KRTAP21-1 →	+0.014	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR2A2 →	+0.046	+4.215	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,544 associations by consensus.

PNLIPRP1 by NPC1 expression — CNS

Explore this box plot interactively →