NPBWR2

Across TCGA patient cohorts, NPBWR2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPBWR2-associated genes across cancer lineages are p70-S6K_pT389, 4E-BP1, and Cyclin-E2. Each is linked with NPBWR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPBWR2-to-partner and partner-to-NPBWR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by NPBWR2-low versus NPBWR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPBWR2→partner) and Y-score (partner→NPBWR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.290	-3.160	.005	.019	2	2
UCEC	4E-BP1 →	+0.400	+2.837	.007	.035	3	1
UCEC	Cyclin-E2 →	+0.215	+2.817	.020	.036	3	1
SKCM	Heregulin →	+0.299	+2.820	.001	.035	3	1
SKCM	Annexin_VII →	+0.244	+3.169	.002	.019	3	1
UCEC	mTOR_pS2448 →	-0.284	-3.169	<.001	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

p70-S6K_pT389 by NPBWR2 expression — UCEC

Explore this box plot interactively →