Across TCGA patient cohorts, NPBWR1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPBWR1-associated genes across cancer lineages are FoxM1, JNK2, and Ku80. Each is linked with NPBWR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPBWR1-to-partner and partner-to-NPBWR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPBWR1→partner) and Y-score (partner→NPBWR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.317	+2.817	.008	.036	3	1
UCEC	JNK2 →	+0.247	+2.834	.007	.034	3	1
UCEC	Ku80 →	+0.303	+3.713	.005	<.001	3	1
UCEC	MEK1 →	+0.365	+3.000	.032	.036	3	1
UCEC	NF2 →	+0.248	+2.584	.014	.011	3	1
UCEC	Caspase-8 →	-0.247	-2.973	.035	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

NPBWR1 survival (RNA) · tumor vs normal (RNA) · all NPBWR1 data types