NPAT

Across TCGA patient cohorts, NPAT protein abundance is significantly associated with the RNA expression of many other genes, with 4,484 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NPAT-associated genes across cancer lineages are CHEK1, MCM5, and BRD2. Each is linked with NPAT in more than 3 cancer types. Because this analysis shows association rather than direction, both NPAT-to-partner and partner-to-NPAT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPAT versus CHEK1 in GBM, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAT→partner) and Y-score (partner→NPAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CHEK1 →	+0.923	+0.376	<.001	<.001	3	4
OV	MCM5 →	+0.693	+0.404	.006	.002	3	3
LSCC	BRD2 →	+0.292	+0.199	.008	.002	3	3
OV	MCM4 →	+0.790	+0.353	.003	.006	3	3
LSCC	CCDC15 →	+0.603	+0.263	<.001	<.001	3	3
OV	CWF19L2 →	+0.440	+0.339	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,484 associations by consensus.

NPAT vs CHEK1 — GBM

Explore this scatter interactively →