NPAT

Across TCGA patient cohorts, NPAT mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPAT-associated genes across cancer lineages are Cyclin-B1, ASNS, and Cyclin-E2. Each is linked with NPAT in more than 3 cancer types. Because this analysis shows association rather than direction, both NPAT-to-partner and partner-to-NPAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NPAT-low versus NPAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAT→partner) and Y-score (partner→NPAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.682	+3.392	<.001	<.001	3	4
COAD	ASNS →	+0.675	+3.000	<.001	.034	3	3
COAD	Cyclin-E2 →	+0.554	+2.832	<.001	.034	3	3
UCEC	eEF2 →	+0.242	+2.000	.019	.029	3	3
UCEC	S6_pS240_S244 →	+0.267	+1.678	.023	.021	3	3
UCEC	MEK1 →	+0.397	+1.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Cyclin-B1 by NPAT expression — UCEC

Explore this box plot interactively →