NPAT

Across TCGA cell cohorts, NPAT mutation is significantly associated with the RNA expression of many other genes, with 1,100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPAT-associated genes across cancer lineages are LRIT2, FOXI2, and SMIM36. Each is linked with NPAT in more than 1 cancer types. Because this analysis shows association rather than direction, both NPAT-to-partner and partner-to-NPAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT2 grouped by NPAT-low versus NPAT-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAT→partner) and Y-score (partner→NPAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LRIT2 →	+0.005	+4.169	<.001	.008	3	2
CNS	FOXI2 →	+0.009	+4.321	<.001	.009	3	2
BLOOD_Leukemia	SMIM36 →	+0.059	+3.269	<.001	.007	3	2
LARGE_INTESTINE	RDH16 →	+0.440	+1.850	<.001	.006	3	2
LARGE_INTESTINE	ME2 →	+1.139	+3.043	<.001	<.001	3	2
LARGE_INTESTINE	ALG6 →	+0.610	+3.129	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,100 associations by consensus.

LRIT2 by NPAT expression — BONE

Explore this box plot interactively →