NPAS3

Across TCGA patient cohorts, NPAS3 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPAS3-associated genes across cancer lineages are Chk1, ASNS, and DJ-1. Each is linked with NPAS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPAS3-to-partner and partner-to-NPAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by NPAS3-low versus NPAS3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS3→partner) and Y-score (partner→NPAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Chk1 →	+0.260	+2.179	.007	.035	3	3
COAD	ASNS →	+0.716	+2.815	<.001	.036	3	3
SKCM	DJ-1 →	+0.315	+2.115	<.001	.017	3	3
UCEC	mTOR_pS2448 →	-0.120	-1.565	.011	.017	3	3
UCEC	Rictor_pT1135 →	-0.071	-1.289	.028	.023	3	3
UCEC	TIGAR →	+0.148	+2.405	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Chk1 by NPAS3 expression — LUSC

Explore this box plot interactively →