NPAS3

Across TCGA cell cohorts, NPAS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,279 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NPAS3-associated GO terms across cancer lineages are Autophagy, Macroautophagy, and Pyramidal neuron differentiation. Each is linked with NPAS3 in more than 6 cancer types. Because this analysis shows association rather than direction, both NPAS3-to-partner and partner-to-NPAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Autophagy grouped by NPAS3-low versus NPAS3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS3→partner) and Y-score (partner→NPAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Autophagy →	+0.075	+0.267	<.001	.007	3	7
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.080	+0.291	<.001	.003	3	7
OVARY	Pyramidal neuron differentiation →	+0.103	+0.725	<.001	.005	3	7
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.075	+0.267	<.001	.007	3	7
SOFT_TISSUE	Host-mediated activation of viral genome replication →	+0.106	+0.937	<.001	<.001	3	6
OESOPHAGUS	Positive regulation of double-strand break repair →	+0.076	+0.706	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,279 associations by consensus.

Autophagy by NPAS3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →