NPAS3

Across TCGA cell cohorts, NPAS3 mutation is significantly associated with the RNA expression of many other genes, with 1,009 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPAS3-associated genes across cancer lineages are CT45A2, CD300H, and H2BC1. Each is linked with NPAS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPAS3-to-partner and partner-to-NPAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT45A2 grouped by NPAS3-low versus NPAS3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS3→partner) and Y-score (partner→NPAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CT45A2 →	+1.960	+4.417	<.001	.004	3	2
OVARY	CD300H →	+0.047	+5.196	<.001	.005	3	2
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR11H12 →	+0.053	+4.222	<.001	.007	3	1
SOFT_TISSUE	CT45A9 →	+1.170	+4.635	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,009 associations by consensus.

CT45A2 by NPAS3 expression — SOFT_TISSUE

Explore this box plot interactively →