NPAS3

Across TCGA cell cohorts, NPAS3 mutation is significantly associated with the mutation status of many other genes, with 6,783 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPAS3-associated genes across cancer lineages are NPAP1, PLXNA4, and ZNF142. Each is linked with NPAS3 in more than 5 cancer types. Because this analysis shows association rather than direction, both NPAS3-to-partner and partner-to-NPAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAP1 grouped by NPAS3-low versus NPAS3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS3→partner) and Y-score (partner→NPAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NPAP1 →	+3.608	+3.906	.004	.004	1	6
BLOOD_Leukemia	PLXNA4 →	+2.728	+3.375	.003	.003	1	6
LUNG_NSCLC_LUAD	ZNF142 →	+5.303	+4.339	<.001	<.001	1	6
BLOOD_Leukemia	SMPD3 →	+3.465	+3.913	<.001	<.001	1	6
BLOOD_Leukemia	TLL1 →	+4.050	+4.260	<.001	<.001	1	6
LUNG_NSCLC_LUAD	HIVEP1 →	+3.133	+3.906	.001	.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,783 associations by consensus.

NPAP1 by NPAS3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →