NPAS2

Across TCGA patient cohorts, NPAS2 mutation is significantly associated with the RNA expression of many other genes, with 4,958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPAS2-associated genes across cancer lineages are CCM2L, TXNL4A, and MRPS18C. Each is linked with NPAS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPAS2-to-partner and partner-to-NPAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCM2L grouped by NPAS2-low versus NPAS2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS2→partner) and Y-score (partner→NPAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CCM2L →	-0.414	-3.421	.003	.005	3	3
UCEC	TXNL4A →	+0.437	+2.087	<.001	<.001	3	3
UCEC	MRPS18C →	+0.353	+2.290	<.001	<.001	3	3
UCEC	BTNL9 →	-0.873	-2.033	<.001	<.001	3	3
UCEC	GLOD4 →	+0.480	+2.055	<.001	<.001	3	3
SKCM	FTH1P12 →	+0.554	+2.019	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,958 associations by consensus.

CCM2L by NPAS2 expression — SKCM

Explore this box plot interactively →