NPAS2

Across TCGA patient cohorts, NPAS2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPAS2-associated genes across cancer lineages are PCNA, eIF4G, and FoxM1. Each is linked with NPAS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPAS2-to-partner and partner-to-NPAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NPAS2-low versus NPAS2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS2→partner) and Y-score (partner→NPAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.248	+2.000	.004	.031	3	3
UCEC	eIF4G →	+0.209	+1.874	.034	.049	3	2
UCEC	FoxM1 →	+0.169	+1.523	.040	.008	3	2
UCEC	Ku80 →	+0.266	+1.790	<.001	.001	3	2
UCEC	MEK1 →	+0.396	+2.321	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.337	+2.058	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PCNA by NPAS2 expression — SKCM

Explore this box plot interactively →