NPAS2

Across TCGA cell cohorts, NPAS2 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NPAS2-associated genes across cancer lineages are OR52I2, MAGEB5, and FAM24A. Each is linked with NPAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPAS2-to-partner and partner-to-NPAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52I2 grouped by NPAS2-low versus NPAS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS2→partner) and Y-score (partner→NPAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR52I2 →	+0.023	+3.580	<.001	.001	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	FAM24A →	+0.035	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CT45A8 →	+0.018	+3.115	.003	.004	3	1
BLOOD_Leukemia	GSC →	+0.746	+2.948	.005	.008	3	1
BLOOD_Leukemia	ASB10 →	+0.074	+3.381	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR52I2 by NPAS2 expression — BLOOD_Leukemia

Explore this box plot interactively →