NPAS1

Across TCGA pan-cancer cohorts, NPAS1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NPAS1 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NPAS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NPAS1 expression acts as an unfavorable survival marker.

HNSC, PDAC, and LSCC are the cancer types where NPAS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.564	0.894	.002	47	view →
PDAC	DFS	Median	IV	0.255	0.741	.038	3	view →
LSCC	OS	Median	All	0.633	1.000	.014	1	view →
CCRCC	DFS	Tertile	All	0.791	1.000	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NPAS1–HNSC (OS)

Open the HNSC breakdown →