NPAS1

Across TCGA patient cohorts, NPAS1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPAS1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PDCD4, and Cyclin-E2. Each is linked with NPAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPAS1-to-partner and partner-to-NPAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by NPAS1-low versus NPAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS1→partner) and Y-score (partner→NPAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.616	-3.000	.008	.036	3	1
UCEC	PDCD4 →	-0.793	-2.990	.001	.036	2	2
SKCM	Cyclin-E2 →	+0.216	+2.820	.016	.035	3	1
UCEC	Notch1 →	+0.315	+3.321	<.001	.010	2	1
UCEC	PCNA →	+0.303	+3.000	.007	.036	2	1
UCEC	TIGAR →	+0.192	+3.348	.016	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p38-MAPK_pT180_Y182 by NPAS1 expression — UCEC

Explore this box plot interactively →