NPAS1

Across TCGA cell cohorts, NPAS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,626 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NPAS1-associated GO terms across cancer lineages are Positive regulation of transcription initiation by RNA polymerase II, Purine nucleoside triphosphate biosynthetic process, and Purine ribonucleoside triphosphate biosynthetic process. Each is linked with NPAS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both NPAS1-to-partner and partner-to-NPAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription initiation by RNA polymerase II grouped by NPAS1-low versus NPAS1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS1→partner) and Y-score (partner→NPAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of transcription initiation by RNA polymerase II →	+0.080	+0.901	<.001	<.001	3	12
OESOPHAGUS	Purine nucleoside triphosphate biosynthetic process →	+0.120	+1.416	.001	<.001	3	12
OESOPHAGUS	Purine ribonucleoside triphosphate biosynthetic process →	+0.120	+1.416	.001	<.001	3	12
OESOPHAGUS	Cellular respiration →	+0.116	+1.551	.002	<.001	3	12
BONE	Regulation of translational initiation →	+0.072	+1.520	.007	<.001	3	12
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.171	+1.877	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,626 associations by consensus.

Positive regulation of transcription initiation by RNA polymerase II by NPAS1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →