Across TCGA pan-cancer cohorts, NPAP1 Mutation is linked to patient survival in 15 of 34 cancer types, making it a survival-associated NPAP1 data layer compared with 22 for mass-spec protein.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NPAP1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NPAP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.
UCEC, READ, and BRCA are the cancer types where NPAP1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.