Across TCGA cell cohorts, NPAP1 mutation is significantly associated with the RNA expression of many other genes, with 669 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPAP1-associated genes across cancer lineages are NCR3, PPM1M, and TTC21B. Each is linked with NPAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPAP1-to-partner and partner-to-NPAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAP1→partner) and Y-score (partner→NPAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NCR3 →	+0.088	+1.747	.003	.004	3	3
LARGE_INTESTINE	PPM1M →	+0.896	+2.265	<.001	.001	3	3
LUNG_NSCLC_LUAD	TTC21B →	+0.532	+3.700	.001	<.001	3	2
LUNG_NSCLC_LUAD	SLC2A11 →	+0.576	+2.378	.003	.008	3	2
LUNG_NSCLC_LUAD	CENPC →	+0.451	+3.321	<.001	.002	3	2
LUNG_NSCLC_LUAD	WRN →	+0.453	+1.943	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 669 associations by consensus.

Exploration

NPAP1 survival (RNA) · tumor vs normal (RNA) · all NPAP1 data types