NOXRED1

Across TCGA patient cohorts, NOXRED1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOXRED1-associated genes across cancer lineages are ERK2, EGFR_pY1068, and GAPDH. Each is linked with NOXRED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOXRED1-to-partner and partner-to-NOXRED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NOXRED1-low versus NOXRED1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOXRED1→partner) and Y-score (partner→NOXRED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.175	+2.321	.027	.006	3	2
UCEC	EGFR_pY1068 →	-0.301	-3.000	.003	.001	3	1
UCEC	GAPDH →	+0.437	+2.321	.048	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.162	-2.459	.020	.019	3	1
UCEC	MEK1 →	+0.410	+1.807	.006	.027	3	1
UCEC	mTOR_pS2448 →	-0.129	-2.439	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ERK2 by NOXRED1 expression — UCEC

Explore this box plot interactively →