Across TCGA pan-cancer cohorts, NOXA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NOXA1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NOXA1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NOXA1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where NOXA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	1.000	0.418	.005	20	view →
PDAC	DFS	Median	All	0.748	0.368	.006	9	view →
LUAD	DFS	Tertile	All	0.427	1.000	.013	5	view →
HNSC	DFS	Tertile	III,IV	1.000	0.533	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: NOXA1 tumor-vs-normal RNA expression · all NOXA1 data types