Across TCGA patient cohorts, NOXA1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOXA1-associated genes across cancer lineages are MEK1, VHL, and Bax. Each is linked with NOXA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOXA1-to-partner and partner-to-NOXA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOXA1→partner) and Y-score (partner→NOXA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.448	+3.000	.034	.036	3	1
UCEC	VHL →	-1.489	-3.000	<.001	.037	3	1
UCEC	Bax →	+0.292	+3.000	.035	.037	3	1
UCEC	PDCD4 →	-0.663	-3.000	.014	.037	1	2
UCEC	ERK2 →	+0.260	+3.000	.019	.037	1	1
UCEC	PKC-a →	+0.546	+3.000	.019	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

NOXA1 survival (RNA) · tumor vs normal (RNA) · all NOXA1 data types