NOX5

Across TCGA cell cohorts, NOX5 mutation is significantly associated with the RNA expression of many other genes, with 247 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOX5-associated genes across cancer lineages are WDR48, OOSP4A, and TSPY4. Each is linked with NOX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOX5-to-partner and partner-to-NOX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR48 grouped by NOX5-low versus NOX5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOX5→partner) and Y-score (partner→NOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR48 →	+0.525	+3.321	<.001	.003	3	2
LARGE_INTESTINE	OOSP4A →	+0.072	+2.278	<.001	.003	3	2
PANCREAS	TSPY4 →	+0.050	+5.614	<.001	.002	3	1
LUNG_SCLC	IL36A →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	GKN1 →	+0.228	+4.044	<.001	.009	3	1
LUNG_SCLC	OR7G3 →	+0.047	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 247 associations by consensus.

WDR48 by NOX5 expression — LARGE_INTESTINE

Explore this box plot interactively →