NOX4

Across TCGA cell cohorts, NOX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,350 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NOX4-associated GO terms across cancer lineages are Biological process involved in interaction with symbiont, Neurotransmitter transport, and Positive regulation of nitric oxide mediated signal transduction. Each is linked with NOX4 in more than 5 cancer types. Because this analysis shows association rather than direction, both NOX4-to-partner and partner-to-NOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Biological process involved in interaction with symbiont grouped by NOX4-low versus NOX4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOX4→partner) and Y-score (partner→NOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Biological process involved in interaction with symbiont →	+0.143	+0.563	<.001	<.001	3	5
BONE	Neurotransmitter transport →	-0.086	-1.233	.001	.003	3	5
SOFT_TISSUE	Positive regulation of nitric oxide mediated signal transduction →	-0.284	-0.488	<.001	.003	3	4
SKIN	Adiponectin-activated signaling pathway →	+0.060	+1.108	.005	.001	3	4
SKIN	Potassium ion transport →	-0.047	-1.141	<.001	.003	1	6
OVARY	Calcium-mediated signaling →	-0.052	-0.906	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,350 associations by consensus.

Biological process involved in interaction with symbiont by NOX4 expression — SOFT_TISSUE

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